diff --git a/.ci/scripts/calculate_jobs.py b/.ci/scripts/calculate_jobs.py
index 5249acdc5d..d696403913 100755
--- a/.ci/scripts/calculate_jobs.py
+++ b/.ci/scripts/calculate_jobs.py
@@ -120,6 +120,7 @@ sytest_tests = [
         "postgres": "multi-postgres",
         "workers": "workers",
         "reactor": "asyncio",
+        "failure_allowed": True,
     },
 ]
 
diff --git a/.github/workflows/tests.yml b/.github/workflows/tests.yml
index 848240f68e..dfb269b92e 100644
--- a/.github/workflows/tests.yml
+++ b/.github/workflows/tests.yml
@@ -525,6 +525,11 @@ jobs:
       - name: Run SyTest
         run: /bootstrap.sh synapse
         working-directory: /src
+        # Prevent failures of this configuration from causing all of CI to
+        # marked as failed. This is useful for testing a new Synapse configuration
+        # in anger without causing sporatic CI failures.
+        continue-on-error: ${{ matrix.job.failure_allowed || false }}
+
       - name: Summarise results.tap
         if: ${{ always() }}
         run: /sytest/scripts/tap_to_gha.pl /logs/results.tap