diff --git a/changelog.d/19221.misc b/changelog.d/19221.misc
new file mode 100644
index 0000000000..d1faf9cb72
--- /dev/null
+++ b/changelog.d/19221.misc
@@ -0,0 +1 @@
+Auto-fix trailing spaces in multi-line strings and comments when running the lint script.
\ No newline at end of file
diff --git a/pyproject.toml b/pyproject.toml
index 3e23823362..b795cba238 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -269,6 +269,8 @@ extend-safe-fixes = [
     "UP007",
     # pyupgrade rules compatible with Python >= 3.10
     "UP045",
+    # Allow ruff to automatically fix trailing spaces within a multi-line string/comment.
+    "W293"
 ]
 
 [tool.ruff.lint.isort]