diff --git a/synapse/storage/_base.py b/synapse/storage/_base.py
index 6b68d8720c..3d98d3f5f8 100644
--- a/synapse/storage/_base.py
+++ b/synapse/storage/_base.py
@@ -69,6 +69,7 @@ class SQLBaseStore(metaclass=ABCMeta):
             self._attempt_to_invalidate_cache("is_host_joined", (room_id, host))
 
         self._attempt_to_invalidate_cache("get_users_in_room", (room_id,))
+        self._attempt_to_invalidate_cache("get_users_in_room_with_profiles", (room_id,))
         self._attempt_to_invalidate_cache("get_room_summary", (room_id,))
         self._attempt_to_invalidate_cache("get_current_state_ids", (room_id,))